Fenproporex treatment in male mice: behavior and toxicology reproductive analysis - DOI: 10.4025/actascihealthsci.1089

Abstract

Fenproporex is used worldwide as a powerful anorectic drug. This study was designed to evaluate whether daily intake of fenproporex would lead to behavioral and/or reproductive toxicity in adult male mice. Fourty male mice were used, divided into 4 groups of 10 animals each. The control group received only water by gavage, whereas the experimental groups were treated daily with fenproporex in the doses of 7.5, 15 and 30 mg kg-1, for a period of 40 days. The results demonstrated that fenproporex did not alter the normal evolution of the animals’ body mass; it also showed that the use of the drug did not promote behavioral toxicity (open-field and forced-swimming tests) or reproductive toxicity (genotoxicity, changes in the morphology of spermatozoa and testicular histology). Thus, the present results indicate that fenproporex, in the evaluated dose and experimental conditions, does not present behavioral and reproductive toxic potential in mice