Mutagenic effect of contaminated soil on the offspring of exposed rats

Auteurs-es

  • Edariane Menestrino Garcia Universidade Federal do Rio Grande do Norte Auteur
  • Flavio Manoel Rodrigues da Silva Junior Universidade Federal do Rio Grande Auteur
  • Ana Luiza Muccillo-Baisch Universidade Federal do Rio Grande Auteur

DOI :

https://doi.org/10.4025/actascihealthsci.v38i1.28545

Mots-clés :

soil contamination, reproduction, wistar rats, metals, micronucleus

Résumé

This study aimed to measure irreversible DNA damage in the offspring of rats exposed to contaminated soil. Bone marrow cells were removed from the femurs of the offspring of rats that were exposed to contaminated soil via gavage during three different periods: 21 days prior to detection of pregnancy, during pregnancy and 21 days after birth, during the lactation period. For each group, we also had a control group under the same experimental conditions but exposed to uncontaminated soil. The results showed that pups borne of rats exposed to contaminated soil had an increase in the number of micronuclei in the different exposure groups compared with their respective control groups. This suggests a potential risk of mutagenic damage to the offspring of pregnant women who live at the sampling site.

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Biographie de l'auteur-e

  • Edariane Menestrino Garcia, Universidade Federal do Rio Grande do Norte
    Programa de Pós-Graduação em Ciências da Saúde, Faculdade de Medicina. Formação, enfermeira.

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Publié

2016-06-08

Numéro

Rubrique

Ciências da Saúde

Comment citer

Garcia, E. M., Silva Junior, F. M. R. da, & Muccillo-Baisch, A. L. (2016). Mutagenic effect of contaminated soil on the offspring of exposed rats. Acta Scientiarum. Health Sciences, 38(1), 19-22. https://doi.org/10.4025/actascihealthsci.v38i1.28545

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