Atividade farmacológica do extrato hidroetanólico liofilizado de caule de Kielmeyera coriacea em ratos - DOI: 10.4025/actascihealthsci.v26i2.1591

Juliana Vanessa Colombo Martins; Fernanda Jacques Otobone; Vania Ramos Sela; Simoni Obici; Marcos Alberto Trombelli; Diógenes Aparício Garcia Cortez; Elisabeth Aparecida Audi

doi:10.4025/actascihealthsci.v26i2.1591

**Activity of hydroethanolic extract from Kielmeyera coriacea stems on central nervous system in rats** - DOI: 10.4025/actascihealthsci.v26i2.1591

Authors

Juliana Vanessa Colombo Martins UEM Author
Fernanda Jacques Otobone UEM Author
Vania Ramos Sela UEM Author
Simoni Obici UEM Author
Marcos Alberto Trombelli UEM Author
Diógenes Aparício Garcia Cortez UEM Author
Elisabeth Aparecida Audi UEM Author

DOI:

https://doi.org/10.4025/actascihealthsci.v26i2.1591

Keywords:

Kielmeyera coriacea, depressão, campo-aberto, teste do nado forçado, labirinto em cruz-elevado

Abstract

The aim of the present study was to investigate psychotropic properties of the crude lyophilized hydroethanolic extract (HE) from Kielmeyera coriacea stems after acute or chronic administration by oral route (gavage) in rats. Anxiolytic, antidepressive and psychomotor stimulant effects were evaluated using Plus-Maze (PMT), Forced Swimming (FST) and Open Field (OFT) test experimental models, respectively. Evaluation of the extract stems (60.0 mg/kg) revealed decreased immobility time in the forced swimming test (FST), without increasing locomotor activity in OFT, after chronic administration. This effect of the extract was compared with imipramine (20.0 mg/kg). Acute administration of 120.0 mg/kg of extract stems increased the open arm entries percentage in the PMT. According to the results, Kielmeyera coriacea stems extract is effective as anxiolytic as well as an anti-depressive-like drugs.

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Author Biography

Elisabeth Aparecida Audi, UEM

Graduada em Ciências Biológicas pela Universidade Estadual de Londrina (1980), com mestrado e doutorado pelo departamento de Farmacologia da Faculdade de Medicina da Universidade de São Paulo (1984/1987). Pós doutorado no Synthelabo-Recherche (1993). Professora associada C da Universidade Estadual de Maringá. Pesquisadora na área de Neuropsicofarmacologia, com ênfase em Substratos Neurais da Ansiedade e Depressão e envolvimento da serotonina no mecanismo de ação de antidepressivos Currículo Lattes

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Published

2008-03-31

Issue

Vol. 26 No. 2 (2004)

Section

Pharmacy

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How to Cite

Activity of hydroethanolic extract from Kielmeyera coriacea stems on central nervous system in rats - DOI: 10.4025/actascihealthsci.v26i2.1591. (2008). Acta Scientiarum. Health Sciences, 26(2), 365-368. https://doi.org/10.4025/actascihealthsci.v26i2.1591