Efeito do extrato bruto hidroalcoólico e de frações de folhas da Averrhoa carambola L. (Oxalidaceae) no metabolismo glicêmico de ratos Wistar

Marilene Provasi; Carlos Eduardo de Oliveira; Luís Cláudio Fernandes; Osvaldo Tchaikovski; ROberto Barbosa Bazotte; Lucia Elaine Ranieri Cortez; Diógenes Aparício Garcia Cortez

doi:10.4025/actascihealthsci.v27i1.1441

Effect of Hydroalcoholic extract and fractions of Averrhoa carambola L. (Oxalidaceae) leaves on the glycemic metabolism of Wistar rats

Authors

Marilene Provasi UEM Author
Carlos Eduardo de Oliveira UEM Author
Luís Cláudio Fernandes UFPR Author
Osvaldo Tchaikovski UFPR Author
ROberto Barbosa Bazotte UEM Author
Lucia Elaine Ranieri Cortez UNIPAR Author
Diógenes Aparício Garcia Cortez UEM Author

DOI:

https://doi.org/10.4025/actascihealthsci.v27i1.1441

Keywords:

Averrhoa carambola L. Oxalidaceae, carambola, atividade hipoglicemiante, açúcares

Abstract

Carambola (Averrhoa carambola L.) leaves have been used for the production of Glico-Vitae^®, a phytotherapic medicine indicated for type 2 diabetes mellitus. Male Wistar rats, which received intragastric administration of the liophyliled extract (EC) and fractions of EC (20 mg/kg) during 2 weeks, showed decreased (p < 0.05) blood glucose levels. However, in contrast to insulin, EC and its fractions neither increased the glycogen synthesis or the lactate production in isolated soleus muscle. In addition, by using spectroscopic methods (MS, NMR¹H and NMR¹³C) a mixture of complex sugars were obtained from the fraction with the highest activity

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Author Biography

Diógenes Aparício Garcia Cortez, UEM

Possui graduação em Farmácia Bioquímica pela Universidade de São Paulo (1974), mestrado em Química pela Universidade Federal de São Carlos (1988) e doutorado em Química pela Universidade Federal de São Carlos (1993). Pós-Doutorado em farmacognosia na Universite de Lausanne (Suiça) (1997). Atualmente é professor Associado da Universidade Estadual de Maringá, departamento de farmácia e farmacologia. Tem experiência na área de Farmácia, com ênfase em Farmacognosia, atuando principalmente nos seguintes temas: fitoquímica, controle de qualidade, validação de fitoterápicos, antimicrobianos, kielmeyera coriacea, xantonas, atividades biológicas e piperaceae Currículo Lattes

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Published

2008-03-26

Issue

Vol. 27 No. 1 (2005)

Section

Pharmacy

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How to Cite

Effect of Hydroalcoholic extract and fractions of Averrhoa carambola L. (Oxalidaceae) leaves on the glycemic metabolism of Wistar rats. (2008). Acta Scientiarum. Health Sciences, 27(1), 45-48. https://doi.org/10.4025/actascihealthsci.v27i1.1441