Maternal exposure of triclosan cause intrauterine development restriction, delay in puberty installation and deregulation of testicular function in rat offspring

Camila Stacheski Machado; João Paulo de Arruda Amorim; Romário Willian Welter; Michael Aparecido Machado; Elaine Manoela Porto Amorim

doi:10.4025/actascihealthsci.v41i1.37929

Maternal exposure of triclosan cause intrauterine development restriction, delay in puberty installation and deregulation of testicular function in rat offspring

Authors

Camila Stacheski Machado Universidade Estadual do Oeste do Paraná Author
João Paulo de Arruda Amorim Universidade Estadual do Oeste do Paraná Author
Romário Willian Welter Universidade Estadual do Oeste do Paraná Author
Michael Aparecido Machado Universidade Estadual do Oeste do Paraná Author
Elaine Manoela Porto Amorim Universidade Estadual do Oeste do Paraná Author

DOI:

https://doi.org/10.4025/actascihealthsci.v41i1.37929

Keywords:

triclosan, endocrine desregulation, puberty, spermatogenesis, rat.

Abstract

This study aimed to evaluate the effects of maternal exposure to triclosan (TCS), during gestation and lactation on physical development, puberty installation and testicular function of male offspring in puberty and sexual maturity. Sixteen pregnant Wistar rats were used and divided into four experimental groups: GI- they received corn oil daily by gavage; GII- they received 75 mg kg^-1 day^-1 of TCS; GIII- they received 150 mg kg^-1 day^-1 of TCS and GIV- they received 300 mg kg^-1 day^-1 of TCS during pregnancy and lactation. The mean weight of the treated rat’s offspring was lower in comparison to GI group. In the exposed offspring. A delay in puberty installation was observed following the exposure to triclosan. Regarding to the stages of the seminiferous epithelium in puberty, it was noticed an increase of the I-VI stages in GIV group, compared with to GI. In sexual maturity, it was observed an increase of VII-VIII, IX-XIII in contrast to a reduction of XIV stage in treated animals, comparing to GI. There was no difference in the number of Sertoli cells. We conclude that the maternal exposure to TCS during gestation and lactation causes restriction of the intrauterine development, delay in the puberty installation and deregulation in the seminiferous epithelium cycle.

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Author Biographies

Camila Stacheski Machado, Universidade Estadual do Oeste do Paraná

Author have declared that no conflicts of interest.
João Paulo de Arruda Amorim, Universidade Estadual do Oeste do Paraná

Centro de Ciências Biológicas e da Saúde - CCBS. Ãrea de Histologia e Embriologia.

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Published

2019-05-22

Issue

Vol. 41 (2019): Publicação contínua

Section

Health Sciences

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How to Cite

Maternal exposure of triclosan cause intrauterine development restriction, delay in puberty installation and deregulation of testicular function in rat offspring. (2019). Acta Scientiarum. Health Sciences, 41(1), e37929. https://doi.org/10.4025/actascihealthsci.v41i1.37929