THE EFFECT OF BOLDINE ON BODY COMPOSITION AND CARBOHYDRATE METABOLISM IN OBESE MICE
DOI:
https://doi.org/10.4025/arqmudi.v27iESPECIAL.68213Palabras clave:
Alkaloid, Obesity, LiverResumen
Boldine is an alkaloid widely found in boldo leaves. Recent studies have determined its
potential effect on glycemic and lipidemia control. Because of this, the objective of this work
was to evaluate the effect of boldine on body composition and carbohydrate metabolism in
obese mice induced by a high-calorie diet. 21-day-old male Swiss mice were divided into
control (standard diet), cafeteria (high-calorie diet) and treatment (boldine 20mg/Kg) groups.
After 90 days of treatment, the animals were euthanized, the liver was collected, and
epididymal, retroperitoneal, mesenteric and brown fats were weighed. Obese animals
increased body and fat weight, but boldine treatment decreased body weight (17%) and
abdominal circumference (15%) and reduced retroperitoneal (66%) and mesenteric (33%) fat
weight. Obesity altered the activity of glucokinase and glucose 6-phosphatase in the liver.
However, the treatment decreased glucose 6-phosphatase activity (30%) and increased
glucokinase activity (43%). We conclude that boldine can be a potential preparation for the
management and treating obesity.
Descargas
Referencias
Descargas
Publicado
Número
Sección
Licencia
DECLARAÇÃO DE ORIGINALIDADE E DIREITOS AUTORAIS
Declaro que o presente artigo é original, não tendo sido submetido à publicação em qualquer outro periódico nacional ou internacional, quer seja em parte ou em sua totalidade.
Os direitos autorais pertencem exclusivamente aos autores. Os direitos de licenciamento utilizados pelo periódico é a licença Creative Commons Attribution 4.0 (CC BY ): são permitidos o acompartilhamento (cópia e distribuição do material em qualqer meio ou formato) e adaptação (remix, transformação e criação de material a partir do conteúdo assim licenciado para quaisquer fins, inclusive comerciais.
Recomenda-se a leitura desse link para maiores informações sobre o tema: fornecimento de créditos e referências de forma correta, entre outros detalhes cruciais para uso adequado do material licenciado.
Cómo citar
