Cytotoxic effect caused by cyclophosphamide in body mass and skeletal muscle tissue of trained rats - doi: 10.4025/reveducfis.v22i2.9933

Abstract

The study examined the changes in body mass and skeletal muscle after a high dose of CF in trained rats. Twenty four Wistar male rats were divided into four groups. Half of the animals were subjected to swimming training lasting up to 40 minutes in moderate intensity for 21 days, the others were kept sedentary. After this period, half the animals in each group (exercise and sedentary) received a single dose of CF, while the other received saline. After seven days, the animals were sacrificed. There was less body mass for animals in the trained groups (227.7 ± 16.6 / 232.3 ± 19.7) compared with sedentary groups (254.6 ± 29.3 / 253.8 ± 29.8). There was no difference in absolute and relative weight of muscle, but a decrease in those areas and in the severity of injuries caused by CF in trained animals was observed.